http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1120081-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-83 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-02 |
| filingDate | 1965-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1120081-A |
| titleOfInvention | Improvements in or relating to substituted benzofuranols and the manufacture thereof |
| abstract | Novel benzofuranols of the general formula <FORM:1120081/C2/1> where R1 is H, C1- 6 alkyl or phenyl, and R2 is C1- 6 alkyl or phenyl, are prepared either (a) by reacting an acetaldehyde diacylate of the general formula <FORM:1120081/C2/2> where 'Acyl' is the acyl radical of a hydrocarbon carboxylic acid with an alkanol and an alkali metal alkoxide or hydroxide, (b) by reacting a substituted benzofuranol of the general formula <FORM:1120081/C2/3> where R3 and R4 are C1- 6 alkyl, phenyl, C1- 6 alkylphenyl, C1- 6 alkoxyphenyl or halophenyl, provided that R3 and R4 are not simultaneously selected from phenyl and substituted phenyl, or R3 and R4 taken together with the nitrogen atom constitute a saturated heterocyclic amino radical, with an alkanol and heating in the presence of a strong mineral acid, or (c) by reacting the above amino-benzofuranol with a quaternizing agent in the presence of an alkanol. The 2 - amino - 2,3 - dihydro - 3 - substituted - 5-benzofuranol starting materials are prepared by condensing a (1-alkenyl) amine of the formula R1R2C = CH-NR3R4 with p-benzoquinone, advantageously in the presence of an inert solvent and under substantially anhydrous conditions. Pharmaceutical compositions comprise, as the active ingredient, a benzofuranol of the first general formula above together with a pharmaceutically acceptable carrier. The compositions are useful as sedatives, central nervous depressants and antioxidants. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2283898-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0420570-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0420570-A3 |
| priorityDate | 1964-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.