http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1117836-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d629f98a51b15993f56f9e04fdea237f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1967-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1117836-A |
| titleOfInvention | Process for preparing 17-bromo- and 17-chloro-16ª-lower alkyl-pregnanes |
| abstract | 17-Bromo- and 17-chloro-16a -lower alkyl-20-keto-pregnanes having the general Formula I <FORM:1117836/C2/1> wherein R is hydrogen or acyl, R1 is C1- 8 alkyl, R2 is H or CH3 and X is chloro or bromo and dehydro analogues thereof, are obtained in a process characterized by treating 16-dehydro-20-keto-pregnane of the general Formula II <FORM:1117836/C2/2> or a dehydro analogue thereof, with a lower alkyl magnesium chloride or bromide, the molar ratio of said lower alkyl chloride or bromide to starting steroid initially being between 0.9 and 1.1 and subjecting the 16a -lower alkyl-20-magnesium enolate thus obtained without substantial purification and isolation from the medium wherein it is formed to a treatment with chlorine or bromine, the quantity of chlorine or bromine applied being approximately 0.9 and 1.1 mole per mole of starting 16-dehydro-20-keto steroid. Treatment with the Grignard reagent may be effected in ethereal solution in the presence of a cuprous halide catalyst at 0-5 DEG C. |
| priorityDate | 1966-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.