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filingDate 1965-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a5a6933f0b75676543021978653f1e3
publicationDate 1968-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1113530-A
titleOfInvention Production of 3-substituted phthalimidines
abstract 3-Substituted phthalimidines having the general formulae <FORM:1113530/C4-C5/1> <FORM:1113530/C4-C5/2> wherein the groups X-C-Y and H-C-Y denote radical of a compound having an activated methylene or methyl group respectively, X and Y denote radicals with groups which are electrophilic under the reaction conditions and radicals X and Y may form a ring, and the benzene ring A may be substituted, e.g. by halogen, nitro, alkyl or aryl groups, are obtained by converting phthalodinitrile or a derivative thereof into 3-iminophthalimidine hydrochloride in aqueous alcoholic hydrochloric acid, e.g. at temperatures up to 60 DEG C. and condensing this product with a compound X-CH2-Y or Y-CH3, e.g. methyl cyanoacetate, ethyl cyanoacetate, 2-picoline, 4-picoline, quinaldine, 2,6 - dimethylquinoline, 5,6-benzoquinaldine, 1-phenyl-3-methylpyrazolone and barbituric acid, at 60 DEG C. to 200 DEG C. optionally in presence of an inert solvent, e.g. methyl glycol, isobutanol, N-methylpyrrolidone and dimethylformamide. The products are colourless, yellow, yellow-orange or red crystals having m.ps. above 170 DEG C.ALSO:3-Iminophthalimidine hydrochloride and the 6-phenyl and 6-nitro derivatives thereof are prepared from phthalodinitrile or a corresponding derivative thereof by reaction with aqueous alcoholic hydrochloric acid with stirring at temperatures up to 60 DEG C.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4066653-A
priorityDate 1964-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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