http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1112211-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 |
| filingDate | 1965-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1112211-A |
| titleOfInvention | Derivatives of the antibiotic tylosin |
| abstract | The invention relates to antibacterial antibiotics O-mycaminosyl tylonolide and dihydromycaminosyl tylonolide. O-mycaminosyl tylonolide is a white basic substance, M.P. 115-118 DEG C.; soluble in chloroform, benzene, acetone and methanol, slightly soluble in ether and water; weakly basic, having one titratable group with a pK1a value of 8.0 as determined by electrometric titration in 66% aqueous dimethylformamide; contains 61.73% carbon, 8.78% hydrogen, 2.25% nitrogen and 27.24% oxygen; empirical formula C30H49NO10; in 95% aqueous ethanol, has U.V. absorption max. at 284 mm and E1%1cm. = 315; has distinguishable bonds in the I.R.-spectrum at 2.78, 2.89, 3.37, 3.42, 3.68, 4.11, 5.82, 5.96, 6.15, 6.28, 6.87, 7.12, 7.25, 7.59, 7.88, 8.13, 8.46, 8.60, 8.79, 9.30, 9.47, 9.93, 10.16, 10.43, 10.79, 11.12, 11.54 and 11.97 microns; specific rotation for sodium D light of 8.11 degrees at 25 DEG C. and 0.863% solution in methanol. O-mycaminosyl tylonolide is prepared by heating an aqueous solution of tylosin, desmycosin, macrocin or lactenocin at a temperature of about 70 DEG C. at a pH of 1.5 to 2.5. The reaction mixture is extracted with methylene chloride and the organic phase is discarded. The aqueous phase is adjusted to pH 6.0 with aqueous NH4OH and extracted with methylene chloride to remove unreacted antibiotic. The aqueous phase is adjusted to pH 9.0, extracted with methylene chloride and O-mycaminosyl tylonolide recovered from the organic phase. Dihydro-mycaminosyl tylonolide is obtained in a similar manner from dihydrotylosin, dihydro-desmycosin, dihydromacrocin or dihydrolactenocin. A pharmaceutical composition comprises O-mycaminosyl tylonolide or dihydro-O-mycaminosyl tylonolide and a carrier. |
| priorityDate | 1964-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.