http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1107104-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-135 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 |
| filingDate | 1966-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1107104-A |
| titleOfInvention | Novel sulphonamides and a process for the manufacture thereof |
| abstract | Novel compounds of the formula <FORM:1107104/C2/1> wherein R1 and R4 are optional substituents selected from halogen, amino and C1- 7 alkyl, R2 and R3 are optional C1- 7 alkyl groups, m and q are both zero or m is 2, 3 or 4 and q is 1 (both being other than zero when R3 is present) and n and p are each 1, 2 or 3 (both being 1 when R3 is present and each being 2 or 3 when m and q are both zero), and acid-addition salts thereof are prepared by reacting compounds II with compounds III or compounds IV with compounds V (wherein R10 and R40 are halogen, alkyl, or groups convertible to amino by reduction or hydrolysis, R5 is a protecting group removable by reduction or hydrolysis, and one of X and Y is halogen and the other amino) and reducing or hydrolysing as required, if desired after N-alkylating the sulphonamido groups. Compounds II wherein R3 is absent and compounds III wherein m and q are both zero and prepared by reaction schemes VI -\sY VIII -\sY IIa and IX -\sY XI -\sY XII -\sY IIIa respectively (wherein X1 is halogen). Compounds II wherein R3 may be present are prepared by the reaction scheme VIa -\sY VIIIa - \sY IIb, and compounds III wherein q is 1 and m is 2, 3 or 4 by the reaction scheme IXa -\sY XIa -\sY XIIa -\sY IIIb. Alkanolamines VIa and IXa wherein n and p are both 1 and R2 is absent are prepared by the reaction scheme XIV -\sY XV -\sY XVI. Alkanolamines VI, VIa, IX and IXa wherein R2 is present are prepared by reacting benzaldehyde with compounds XVII to give compounds XVIII, hydrogenating these to compounds XIX, reacting these with an alkyl halide to give compounds XX and hydrogenating these <FORM:1107104/C2/2> <FORM:1107104/C2/3> <FORM:1107104/C2/4> <FORM:1107104/C2/5> <FORM:1107104/C2/6> <FORM:1107104/C2/7> <FORM:1107104/C2/8> <FORM:1107104/C2/9> <FORM:1107104/C2/10> The disulphonamides of the invention, which have cardioactive properties, may be made up into pharmaceutical compositions for oral or intravenal administration with suitable carriers. |
| priorityDate | 1965-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID240 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458396401 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419531457 |
Total number of triples: 18.