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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-10
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filingDate 1966-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1968-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1103178-A
titleOfInvention Process for the production of an isoxazole derivative
abstract 3 - Hydroxy - 5 - isoxazole carboxamide is prepared by heating 3-bromo- or 3-chloroisoxazole-5-carboxylic acid with an alkanol having at most 4 carbon atoms or benzyl alcohol and an alkali metal hydroxide to form a 3 - alkoxy - 5 - isoxazole carboxylic acid having at most 4 carbon atoms in the alkyl group or 3-benzyloxy - 5 - isoxazole carboxylic acid, liberatting 3 - hydroxy - 5 - isoxazole carboxylic acid from these acids by heating with hydrobromic acid, hydrochloric acid, pyridine hydrochloride, pyridine hydrobromide or an alkyl-substituted pyridine hydrochloride or hydrobromide, and converting the 3-hydroxy-5-isoxazole carboxylic acid into 3-hydroxy-5-isoxazole carboxamide by converting it into the acid chloride and reacting the latter with ammonia. The preparation of 3-bromo-5-isoxazole propionic acid and 3-bromo-5-isoxazole carboxylic acid is described.
priorityDate 1965-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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