http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1100643-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34bd4e87ecbca17f16d460ca394e60f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-78 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-78 |
| filingDate | 1965-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1100643-A |
| titleOfInvention | ª-alkyl thyronines and method of preparing these compounds |
| abstract | Novel compounds of the general formula <FORM:1100643/C2/1> (wherein R1 represents a C1- 6 alkyl radical, R2 represents an NH2 or acylated NH2 group, and R3, R4 and R5, which may be the same or different, represent H or I atoms) are prepared by (a) reacting a compound of the general formula <FORM:1100643/C2/2> (wherein R6 and R7 jointly represent -NH-CO-NH- or R6 represents OH or etherified OH and R7 represents NH2 or acylated NH2) with an acid of the general formula <FORM:1100643/C2/3> at substantially neutral pH under anaerobic or aerobic conditions at temperatures below 100 DEG C. and, if necessary, converting R6 and R7 to OH and NH2, or (b) reacting a compound II (but in which R7 is not NH2) with a compound of the general formula <FORM:1100643/C2/4> (wherein R9 represents in alkyl radical and An an anion) in a solvent in the presence of a basic substance, removing the solvent, removing R9 by acid hydrolysis, hydrolysing the hydantoin (when R6 + R7 = -NH-CO-NH-) by warming with dilute aqueous alkaline or mineral acid solutions, and mono- or di-iodinating the product, preferably in alkaline solution, or (c) reacting an activated ester of a compound of the general formula <FORM:1100643/C2/5> (wherein R6 and R8 jointly represent -NH-CO-NH- or R6 represents OH or etherified OH and R8 represents an acylamino group) with a compound of the general formula <FORM:1100643/C2/6> in the presence of a solvent and/or a base, replacing the NO2 groups by R3 and R4 via NH2 and diazo groups and completing the process as in (b), omitting the iodination step when using a compound XI. The products may be converted into salts with inorganic or organic acids or bases, and a free NH2 group in the products may be acylated. The preparation of the following starting materials and intermediates is described: 5 - (31 - iodo - p - hydroxybenzyl) - 5 - methylhydantoin, 5 - (31,51 - dinitro -, - diamino - and - diiodo - 41 - p - methoxyphenoxybenzyl) - 5 - methylhydantoin, 5 - (31,51 - diiodo - 41 - p-hydroxyphenoxybenzyl) - 5 - methylhydantoin, and 3,5 - diiodo - a - methylthyromine (and its sodium salt). Reference has been directed by the Comptroller to Specification 1,047,082. |
| priorityDate | 1964-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.