http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1095665-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C02F5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-569 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C02F5-10 |
| filingDate | 1965-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4a980ec8fd8f96409f18970520d01b5 |
| publicationDate | 1967-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1095665-A |
| titleOfInvention | Novel 9ª‰, 10ª‡-steroids and a process for the manufacture thereof |
| abstract | The invention comprises 3-keto-D 4-, 3-keto-D 4,6-, 3-keto-D 1,4-, 3-keto-D 1,4,6- and 3-acyloxy-D 3,5-derivatives of compounds of formula <FORM:1095665/C2/1> wherein R is a halogen atom, -OR1 is a free, etherified or acylated hydroxy group, X is a hydrogen or halogen atom or a hydroxy or acyloxy group, Y is a hydrogen atom or a free, etherified or acylated hydroxy group and Z is an alkyl, alkenyl or alkynyl group containing up to 5 carbon atoms, and their preparation by (a) reaction of an unsubstituted steroid with an oxalic acid or formic acid ester to obtain a 2 - (carboxy - hydroxy - methylene) or 2 - hydroxy-methylene-compound and reacting this successively with a halogenating agent and a base, (b) direct halogenation, including treatment of 3 - keto - D 1,4,6, 3 - acyloxy - D 2,4,6 and 6-halo-compounds, followed where necessary by partial dehalogenation of a 1,2-dihalo, 2,2-dihalo or 6-halo product, (c) introduction of double bonds into the 1- and/or 6-positions by standard methods, (d) enol etherification (e) interconversion of 17b -hydroxy and 17-keto groups, or (f) ethynylation of a 17-keto-compound. The compounds of the invention have uterotrophic, antigonadotrophic or anti-andro-genic activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral or parenteral administration. |
| priorityDate | 1965-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.