http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1094235-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f05651e7e4bcb2a49f3cdd197707bf26 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-14 |
| filingDate | 1965-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1094235-A |
| titleOfInvention | New heterocyclic amines and a method of preparing same |
| abstract | The invention comprises amines of the general formula <FORM:1094235/C2/1> wherein R1 and R2, identical or different, each stand for a hydrogen atom, lower alkyl (C1-C4), cycloalkyl or dialkylaminoalkyl or R1 and R2 are linked together to one carbon chain which may be interrupted by a hetero atom and substituted, thus forming together with the nitrogen atom a heterocyclic saturated residue and salts thereof and a process for the preparation thereof wherein 10 - chloro - 10,11 - dihydro-dibenzo (b, f) thiepin is brought into reaction with a substance of the formula R1R2NH, wherein R1 and R2 are as defined above and the product optionally converted to a salt with a pharmaceutically convenient acid. Examples describe the preparations of 10-dimethylamino-, 10-amino-, 10-methylamino-, 10-diethylamino-10-piperidino-, 10-(4-phenyl-4-carbethoxypiperidino-, 10-(4-methylpiperazino-, 10-(methyl-hexahydro - 1,4 - diazepin) -, 10 - piperazino - and 10 - (4 - ethylpiperazino) - 10,11 - dihydrodibenzo (b,f) thiepins some of which are isolated as hydrochlorides or maleates. 10 - Chloro - 10,11 - dihydrodibenzo (b,f) thiepin employed as starting material is obtained by reacting diphenylsulphide - o - carboxylic acid with lithium-aliminium hydride, decomposing the product to obtain o - hydroxymethyl-diphenylsulphide, converting the latter successively to the corresponding o-chloro-, o-cyano- and -o-acetic acid compounds, treating the latter with polyphosphoric acid to obtain 10,11 - dihydrodibenzo (b, f) thiepin - 10 - on, reducing the latter with sodium borohydride to the corresponding hydroxy compound and converting the latter to the corresponding 10-chloro-compound by reaction with thionyl chloride. |
| priorityDate | 1964-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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