http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1092748-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 |
| filingDate | 1965-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1092748-A |
| titleOfInvention | Resolution of racemic mixtures of optically active enantiomorphs |
| abstract | Racemic mixtures of optically active enantiomorphs are resolved by (a) preparing a supersaturated solution of the racemic mixture; (b) contacting the supersaturated solution with one of the optically active enantiomorphs in finely-divided solid crystalline form to effect preferential crystallization of said enantiomorph and consequent depletion of the supersaturated solution relative to said enantiomorph; (c) separating the crystalline enantiomorph from the depleted solution; (d) removing the depleted solution to a dissolving zone; (e) bringing the solution to a state in which it is less than saturated with said enantiomorph and saturated with the other enantiomorph; (f) contacting the depleted solution with finely divided solid racemic mixture to selectively dissolve said enantiomorph from the solid racemic mixture and leave the optical antipode as undissolved solid in the dissolving zone, thereby forming a saturated solution of the racemic mixture; (g) separating the resulting saturated solution from the undissolved antipode; and (h) treating the saturated solution to achieve supersaturation relative to the racemic mixture, the racemic mixture having a greater solubility in the selected solvent than either of the two enantiomorphs alone. The undissolved optical antipode obtained in step (g) may be racemized to form a racemic mixture of the optically active enantiomorphs and the racemic mixture may then be returned to the process in step (f). The supersaturated solution may be prepared by cooling a saturated solution of the enantiomorphs, in which case step (e) may be effected by heating. The process may be used to resolve DL - a - acetamido - a - vanillyl - (or a - veratryl - or 3,4 - dihydroxybenzyl-propionitrile, DL - 3 - (3,4 - dihydroxyphenyl)-alanine, DL - N - benzoyl - dichloroamphetamine, DL - threo - 1 - (p - nitrophenyl) - 2-aminopropane - 1,3 - diol, DL - sodium ammonium tartrate, DL-atropine sulphate, DL-dilactyldiamide, DL-histidine monohydrochloride and the racemic mixture of the zinc ammonium salts of lactic acid. |
| priorityDate | 1964-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.