http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1090115-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d037bc74e34c7d73dd883f208aef0518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 |
| filingDate | 1964-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47130a6df155d082b18ae9a8d0d9dae7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_433d9b3d48326e771e4724780afa29ce |
| publicationDate | 1967-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1090115-A |
| titleOfInvention | Mannich bases of rifamycin sv |
| abstract | The invention relates to 3-amino-methyl derivatives of rifamycin SV having the general formula <FORM:1090115/C2/1> wherein B is <FORM:1090115/C2/2> or <FORM:1090115/C2/3> wherein R is H or C1- 8 alkyl, hydroxy C1- 8 alkyl, carboxy C1- 8 alkyl o cycloalkyl, X is methylene, ethylene, -CH2O- or -CH2NH- and R11 and R111 each represent H, C1- 8 alkyl, OH or carboxy; and the N-oxides of said compounds. The compounds are produced by treating rifamycin S with formaldehyde and a compound of formula HB, wherein B is as defined above, and contacting the obtained aminomethyl derivative of rifamycin S with an aqueous solution of ascorbic acid to reduce the quinone system to the hydroquinone system of the desired rifamycin SV derivative. The N-oxides are obtained by treating the 3-amino-methyl derivative of rifamycin SV with aqueous hydrogen peroxide. Therapeutic compositions comprise the above 3-aminomethyl derivatives of rifamycin SV or their N-oxides and a carrier. They have broad spectrum antibacterial activity and may be used orally. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3524845-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010068383-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3542762-A |
| priorityDate | 1964-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.