http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1088353-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5922cbe7c65a9136f85906fa09e7c967 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1965-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1088353-A |
| titleOfInvention | Improvements in or relating to androstene derivatives |
| abstract | 17a - Ethynyl - 19 - nor - D 4 - androsten-17b -ol-3-one is prepared free of 3,17-diones by heating a solution of at least one of the aforementioned compound and its D 5(10)-isomer and at least one of the corresponding 17-ones in an inert organic solvent with dry hydrogen chloride to precipitate 5a -chloro-17a -ethynyl-19 - nor - androstan - 17b - ol - 3 - one and contacting this compound with an alcoholic solution of a strong base to give the required product free of 3,17-diones. The hydrogen chloride may be generated in situ, and preferred solvents are benzene, chloroform and dioxan. The starting materials are prepared by selective ethynylation of the 3,17-diones and this accounts for their presence in them. After the 5a -chloro-compound has been separated the 3,17-diones remaining in solution can be recycled to the ethynylation step. In a modification of the above process the required product is separated from reaction mixtures obtained by the Oppenauer oxidation of 17a -ethynyl-19-nor - D 5(10) - androsten - 3b ,17b - diol, such mixtures comprising the unreacted starting material, and the corresponding 3-one and 3,17-dione and their D 4-isomers, by acylating to give the 3-acylate of the starting material, and then using the resulting mixture as the starting material in the hydrochlorination step. |
| priorityDate | 1964-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.