http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1084247-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-54 |
| publicationNumber | GB-1084247-A |
| abstract | 1,084,247. Pyrazolidine derivatives. BENGER LABORATORIES Ltd. Nov. 10, 1964 [Aug. 20, 1963], No. 32808/63. Heading C2C. Compounds of the Formula (I) in which R<SP>1</SP> is a phenyl, aralkoxyphenyl, pyridylalkyl or sulpholanyl group; R<SP>2</SP> is H or an alkyl, hydroxyalkyl, dialkylaminoalkyl, aralkyl, nitro-substituted aralkyl, pyridylalkyl, phenyl, toluenesulphonyl or sulpholanyl group, or an alkyl group interrupted by a CO group; R<SP>3</SP> is an alkyl or a pyridylalkyl group or, when R<SP>1</SP> and R<SP>2</SP> are sulpholanyl, is H; and R<SP>4</SP> is an alkyl group or a pyridylalkyl group ; or R<SP>3</SP>. and R<SP>4</SP> together with the adjacent carbon atom form a cyclobutane, cyclopentane, cyclohexane, or tetrahydrofuran ring, and acid addition salts of those compounds containing a dialkylaminoalkyl or pyridylalkyl group, are prepared by condensing a hydrazine of the formula where Y is H or MgX, where X is a halogen atom, with an ester, anhydride or acid halide of an acid of the formula or by condensing a compound of the Formula (I) in which one or more of R<SP>1</SP>, R<SP>2</SP>,<SP> </SP>R<SP>3</SP> or R<SP>4</SP> is H with an alkenylpyridine (to give a compound (I) where one or more of R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP> or R<SP>4</SP> is pyridylalkyl) or with an appropriate alkyl, aralkyl, hydroxyalkyl, or dialkylaminoalkyl halide (to give the corresponding compound (I)). Pharmaceutical compositions having antiinflammatory activity comprise the compounds (I) and a carrier therefor. The compositions may be in a form suitable for parenteral or topical administration. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0106251-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2029409-A1 |
| priorityDate | 1963-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.