http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1083724-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 1965-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1083724-A |
| titleOfInvention | N-substituted azabicyclononanes |
| abstract | Novel compounds of general formula <FORM:1083724/C2/1> wherein Ar is phenyl or pyridyl, Y is H, Cl, F, Br or I, Z is NH2, dimethylamino or pyrrolidino and n is 2 or 3, and acid addition salts thereof, are prepared either by hydration of a nitrile of general formula <FORM:1083724/C2/2> to give compounds where Z is NH2 or by condensing the alkali metallo derivative of a compound of general formula <FORM:1083724/C2/3> with a compound of formula <FORM:1083724/C2/4> or by reaction of 3-azabicyclo-[3.2.2]-nonane with a halide of formula <FORM:1083724/C2/5> (Z1 is dimethylamino or pyrrolidino), optionally followed in appropriate cases by salt formation. Nitriles of the second general formula above are prepared either by reaction of 3-azabicyclo-[3.2.2]-nonane with a halide of formula <FORM:1083724/C2/6> or by condensing a halide of Formula IV above with an alkali metallo derivative of an acetonitrile of formula <FORM:1083724/C2/7> which may be prepared in situ by reaction of an appropriate benzyl cyanide, sodamide, and a halopyridine. 5 - Chloro -2,2 - diphenylvaleric acid pyrrolidide is prepared by reaction of trimethylenechlorobromide and the sodium derivative of N-diphenylacetylpyrrolidine. |
| priorityDate | 1964-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.