http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1066729-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30432c021c19453629a3b69ce104640e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1965-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df71e544a3398f4cdbefeb36a12ea655 |
| publicationDate | 1967-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1066729-A |
| titleOfInvention | 6-substituted pregnanes |
| abstract | The invention comprises compounds of formula <FORM:1066729/C2/1> where W is hydrogen, hydroxy or C1- 3 alkanoyloxy, Y is hydrogen or hydroxy, and Z is carbonyl, b -hydroxymethylene or b -C1- 3-alkanoyl-oxymethylene, with the proviso that, when Y is hydrogen, Z is b -hydroxymethylene or b -C1- 3-alkanoyloxymethylene, and their preparation by (a) reaction of a 6-methylene-pregnane with di-methylsulphoxonium methylide, any 17a ,21-dihydroxy compounds being protected by a 17a ,20: 20,21 - bis - methylenedioxy group which is subsequently removed by hydrolysis, followed, if desired, by (b) hydrolysis of a 20b -alkanoyloxy product to a 20b -hydroxy compound, (c) oxidation of a 20b -hydroxy product to a 20-keto compound, or (d) reaction of a 21-hydroxy compound with methane sulphonyl chloride to form the 21-methanesulphonate, reacting this with sodium iodide to form the 21-iodide, and treating this with a reducing agent to form 21-unsubstituted compound. The compounds of the invention have progestational activity. 6 - Methylene - 17a ,20 : 20,21 - bis - methylenedioxy - pregn - en - 3 - one is prepared by reaction of 17a ,20 : 20,21-bis-methylenedioxy-pregn-4-en-3-one with ethyl orthoformate in the presence of an acid catalyst to form the corresponding 3-ethoxy-3,5-diene, reacting this with a mixture of phosgene or phosphorus oxychloride with dimethylformamide to form the 3-ethoxy-6-formyl-3,5-diene, treating this with sodium borohydride to form the 3-ethoxy-6-hydroxymethyl-3,5-diene, and treating this with aqueous acetic acid. |
| priorityDate | 1965-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.