http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1063894-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8e49a2b5f6d0ba32839687472b3a437 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-13 |
| filingDate | 1964-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1063894-A |
| titleOfInvention | Quinazolinedione derivatives |
| abstract | Novel compounds of the Formula I, wherein R1 represents a halogen atom or a nitro, amino or acylamino group; n represents a number from 0-6 inclusive; m represents a number from 0 to 4 inclusive, so that the radicals R1 are the same or different; and R2 represents a di-C1- 4 alkylamino, unsubstituted, phenyl substituted, substituted phenyl substituted or phenalkyl substituted piperazinyl, pyridyl, unsubstituted or phenyl substituted piperidyl, unsubstituted, phenyl substituted, or substituted phenyl substituted piperazinium, morpholinyl or unsubstituted or substituted benzodiazepinyl and pharmacologically acceptable salts thereof, are prepared by reacting an o-aminobenzamide of the Formula II with phosgene, or with ethyl chloroformate to give the corresponding ethoxy-carbamoyl derivative of the Formula III which is cyclized by heating preferably to a temperature above its melting point, or, where R1 represents a nitro group in the 6-position, by dehydrating an urea of the Formula IV and, if desired, converting a resulting piperazinyl compound into a piperazinium compound and, if desired, converting a free base into an acid addition salt thereof. <FORM:1063894/C2/1> <FORM:1063894/C2/2> <FORM:1063894/C2/3> <FORM:1063894/C2/4> o-Aminobenzamides of the Formula II may be prepared by reacting a suitable primary amine with isatoic anhydride or a substituted derivative thereof. 1 - Methyl - 2,3,4,5 - tetrahydro - 1,4 - benzodiazepine and its hydrochloride may be prepared by the action of formaldehyde and formic acid on N-methyl-N-phenylethylenediamine. 4 - Cyanomethyl - 1 - methyl - 2,3,4,5 - tetrahydro - 1,4 - benzodiazepine may be prepared by reacting 1 - methyl - 2,3,4,5 - tetrahydro-1,4-benzodiazepine with sodium bisulphite and formaldehyde and then with potassium cyanide. N - [3 - (4 - Phenyl - 1 - piperazinyl) - propyl]-N1 - (2 - carboxy - 4 - nitrophenyl)urea may be prepared together with 1-[3-(21-amino-51-nitrobenzamido) - propyl] - 4 - phenylpiperazine by reacting 1 - (3 - aminopropyl) - 4 - phenylpiperazine with 6-nitroisatoic anhydride. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0454060-A1 |
| priorityDate | 1963-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.