http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1059800-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70ec63d39d6704bacc5c7068c93ded43 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N57-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N57-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6541 |
| filingDate | 1964-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad9db0564e396b5e793cd7d8e812f2bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d82bcf50913ae03b5c1c56d0083134e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a34bc2440bfa20d2c8d8476e58fff00 |
| publicationDate | 1967-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1059800-A |
| titleOfInvention | Preparation of benzo-thiadiazole derivatives |
| abstract | The invention comprises 7-hydroxy-1,2,3-benzothiadiazole and a general method for making hydroxy-1,2,3-benzothiadiazoles comprising diazotization of the appropriate amino-benzothiazole and acid hydrolysis of the diazotized reaction mixture. Diazotization is effected under known conditions using a concentrated or dilute mineral acid. It is preferred to use a dilute acid as the hydrolysis stage proceeds more rapidly in dilute solution. If a concentrated acid is used in the diazotization step, it is preferred to add water to accelerate the hydrolysis. Hydrolysis also proceeds more rapidly if the mixture is heated to reflux. Examples IV to VI describe the preparation of the 5-, 6- and 7-hydroxy-1,2,3-benzothiadiazoles. The aminobenzothiazole starting materials are prepared by the reduction of the corresponding nitro-compounds. Example III describes the reduction of 7-nitrobenzothiazole using stannous chloride and HCl. The nitrobenzothiazoles are made by nitration of benzothiazole or, for the 5-isomer, by the reaction of 2-mercapto-5-nitroaniline with formic acid. Examples I and II relate to the preparation of the nitro compounds. 2-Mercapto-5-nitroaniline is prepared by reacting 2-bromo-5-nitroaniline with sodium sulphide. |
| priorityDate | 1964-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.