http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1057969-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_334b26d249dc7a2d0df884c87eab5255 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-092 |
| filingDate | 1965-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1057969-A |
| titleOfInvention | Aryloxyamines and process for preparation |
| abstract | Novel o-substituted aryloxyamines of the formula <FORM:1057969/C2/1> wherein R1 and R2 are either the same or different lower alkyl groups, or when taken with the amino nitrogen atom form a closed chain heterocyclic group, R3, R4 and R5 may be the same or different hydrogen or halogen atoms or lower alkyl or lower alkoxy groups or together form a methylenedioxy group; Z is oxygen or sulphur and n is 2 or 3, and the pharmaceutically acceptable acid addition salts thereof are obtained in a process which comprises reacting an aryloxyamine of the formula <FORM:1057969/C2/2> with a benzyl halide of the formula <FORM:1057969/C2/3> wherein Y is halogen, and, if desired, forming the pharmaceutically acceptable salts. The starting compounds may be obtained by reacting o-hydroxybenzaldehyde with the hydrochloride salt of a substituted aminochloroalkane to form o-(substituted amino lower alkoxy)benzaldehyde which is reduced to form the corresponding benzyl alcohol. The benzyl chloride and benzyl thio-alcohol starting compounds are obtained therefrom by treatment with thionyl chloride and sodium hydrosulphide successively. Pharmaceutical compositions having anti-spasmodic, anti-inflammatory, anti-tussive, sedative, anti-pyretic and anti-convulsive activity are administered orally or parenterally. |
| priorityDate | 1964-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.