http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1055078-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1964-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1055078-A |
| titleOfInvention | 17 beta methyl-20-alkyl-18-nor-17 alpha -pregnenes |
| abstract | Novel steroids of the formula <FORM:1055078/C2/1> wherein the A and B rings have one of the structures <FORM:1055078/C2/2> (wherein R is C1-4 alkyl and R1 and R11 ar each either hydrogen or acetyl) are prepared by reacting steroids of the formula <FORM:1055078/C2/3> (wherein the A and B rings have one of the 3-hydroxy or -acyloxy-containing structures depicted above) with an alkyl Grignard reagent at a temperature between - 10 DEG and + 30 DEG C. in an inert, anhydrous, organic solvent with subsequent mild hydrolysis in water, to give a steroid of the first general formula above wherein R11 is hydrogen and the A and B rings are as in the starting material. Then subsequently 3b -acetates are hydrolysed to 3b -ols, the 3b ,16a -diols are acetylated to the diacetates (which can also be obtained by acetylation of the 3-mono-acetates) and these may be hydrolysed to give the 3b ,16a -diols again. The D 5-3-ols or their acylates may be catalytically hydrogenated to the 5,6-saturated compounds. The D 4-3-ones are prepared by oxidation of the D 5-3-ols, and on catalytic hydrogenation they yield the ring A saturated 3-ones. The 16-monoacetoxy compounds are prepared by standard methods from the 3-oxo-16-ols. |
| priorityDate | 1963-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.