http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1054010-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-36 |
| publicationNumber | GB-1054010-A |
| abstract | 1,054,010. 2 - Amino - 5 - halobenzylamines. DR. KARL THOMAE G.m.b.H. Oct. 6, 1965 [Oct. 12, 1964], No. 42422/65. Heading C2C. The invention comprises compounds of the formula and non-toxic acid addition salts thereof, wherein " Hal " is Cl or Br, R and R<SP>1</SP> are unbranched or branched, saturated or unsaturated aliphatic hydrocarbon groups of up to 6 C atoms or hydroxyalkyl, cycloalkyl, aryl, aralkyl or pyridylalkyl groups, or together with the N atom form a pyrrolidino, piperidino, piperazino or hexamethyleneimino group optionally bearing C 1-6 alkyl substituents; together with processes for their preparation by (a) reacting a 2-diacylamino-5-halobenzyl halide with an amine R<SP>1</SP>RNH and removing the acyl groups from the resulting product, e.g. by acid or alkaline hydrolysis; (b) reducing a 5-halo-2- nitrobenzylamine bearing substituents R and R<SP>1</SP> on the amino group; (c) reducing a 2-amino- 5-halo-benzoic (R, R<SP>1</SP>-substituted) amide, e.g. with LiAlH 4 ,or (d) chlorinating or brominating an R, R<SP>1</SP>-substituted 2-acylaminobenzylamine and removing the acyl group by hydrolysis. Pharmaceutical preparations having antipyretic, secretolytic and anti-tussive action comprise the above compounds of the invention and a carrier or excipient. The preparations may take forms adapted to oral, rectal or parenteral administration such as tablets, capsules, suspensions, sterile solutions in water, aqueous polyvinyl pyrrolidone or oils or suppositories. |
| priorityDate | 1963-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.