http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1053085-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-135 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-113 |
| publicationNumber | GB-1053085-A |
| abstract | 1,053,085. Oxadiazoles, thiadiazoles and triazoles. DR. KARL THOMAE G.m.b.H. March 26, 1965 [March 26, 1964], No. 12996/65. Heading C2C. Compounds of the general formula n which R<SP>1</SP> and R<SP>2</SP>, which may be the same or different are C 1-6 -alkyl groups which may optionally be substituted by C 2-6 alkenyl groups, C 6-8 cycloalkyl, C 7-9 aralkyl or C 6-8 aryl groups or R<SP>1</SP> and R<SP>2</SP> together with the N atom to which they are attached for a 5 to 7 membered heterocyclic ring which may be interrupted by a further hetero atom and/or be substituted by lower alkyl groups and/or be fused to a saturated carbocylic ring ; R<SP>3</SP> represents H, C 1-8 alkyl, optionally substituted by dialkylamino, C 2-6 alkenyl, C 6-8 cycloalkyl, C 7-9 aralkyl, C 6-8 aryl, or an acyl group; R<SP>4</SP> represents H, C 1-6 alkyl optionally substituted by C 2-6 alkenyl, C 6-8 cycloalkyl, C 7-9 aralkyl, or C 6-8 aryl, or R<SP>3</SP> and R<SP>4</SP> together with N form a 5-7 membered heterocyclic ring which may contain a further hetero atom and/or be substituted by lower alkyl groups; A represents a bivalent acyclic group of 1-6 C and X is an O or S atom or the -NH group and their acid addition salts are prepared by oxidizing a compound of the formula in the presence of a solvent and at an elevated temperature whereby ring closure occurs or by dehydrating a compound of the formula or by reacting an imidate of the formula (wherein Alk is a lower alkyl group and Hal a halogen atom) with a compound of the formula or (wherein X is an O atom) by reacting an aminoacylhydrazide of the formula with bromocyanogen or by reacting a compound of the formula with a heavy metal oxide in the presence of water or an organic solvent at an elevated temperature ; or by acylating a compound I wherein R<SP>3</SP> is H or by hydrolysing a compound I where R<SP>3</SP> is an acyl group. N<SP>1</SP> (N,N - dimethyl glycyl) - semi carbazide, - thiosemicarbazide and - amino guanidine- N<SP>1</SP>- (N,N<SP>1</SP> - dimethyl - # - alanyl) -, -, N<SP>1</SP> - (N,N- diethyl - # - alanyl) ; . N<SP>1</SP> - (N,N<SP>1</SP> - diallyl glycyl) -, N<SP>1</SP> - morpholinoacetyl -, N<SP>1</SP> - ((#- morpholinopropionyl)- amino guanidines- N<SP>1</SP> - (N - cyclohexyl - N - methyl - glycyl) - thiosemicarbazide and - N<SP>4</SP> - allyl - thiosemicarbazide are named as novel starting materials. Pharmaceutical compositions showing antitussive, analgesic, hyperglycaemic antipyretic activity comprise the compounds I and a suitable carrier. The compositions may be administered either enterally or parenterally. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6124294-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9406773-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5658923-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7074788-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7173030-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9222541-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03044000-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5424312-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6472392-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6403593-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5958923-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004103980-A1 |
| priorityDate | 1964-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.