http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1050737-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 |
| publicationNumber | GB-1050737-A |
| abstract | 1,050,737. Indole derivatives. MERCK & CO. Inc. Jan. 29, 1964 [Feb. 1, 1963], No. 2068/66. Divided out of 1,050,728. Heading C2C. Indole-3-acetic acid derivatives of the formula wherein R 1 is an aryl, heterocyclic aryl or substituted aryl or heterocyclic aryl group, e.g. pchlorophenyls, R 2 is a hydrogen atom or a C 1-5 alkyl, C 2-5 alkenyl, aryl, aralkyl, alkaryl or substituted alkyl or aryl radical, R 3 is hydrogen or a C 1-5 alkyl or C 2-5 alkenyl radical and R 5 is a hydrogen or halogen atom or a C 1-5 alkyl, C 1-5 alkoxy, e.g. CH 3 O, haloalkyl, nitro, amino, substituted amino, cyano, aminomethyl, alkylsubstituted amino methyl, mercapto, dialkysulphamoyl or benzyl mercapto radical, are made by reacting the corresponding 1-unsub stituted compound with at least two equivalents of sodium hydride in an inert solvent, cooling the mixture below room temperature, adding the acyl halide of a carboxylic acid of the formula R 1 COOH to form the mixed anhydride of the acid R 2 COOH and the 1-R.CO-indole-3- acetic acid and agitating this in a dilute aqueous hydrogen halide at a temperature below ambient. The exemplified product is 1-p-chlorobenzoyl - 2 - methyl - 5 - methoxyindole - 3 - acetic acid. |
| priorityDate | 1963-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.