http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1045544-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b6fc801b5bfe5304ffa40d938db6e09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C243-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-34 |
| filingDate | 1964-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1966-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1045544-A |
| titleOfInvention | New derivatives of pyrazolidines their production and use |
| abstract | Novel compounds of formula <FORM:1045544/C2/1> in which R1 is hydrogen, R is an alkyl radical having 1-3 carbon atoms, and n is 2-4, and non-toxic salts thereof with an inorganic or organic base, are prepared (a) by treating compounds in which R1 is an arylmethyl or diarylmethyl radical, with catalytically activated hydrogen until substantially an equimolar amount of hydrogen has been taken up, or (b) subjecting a compound in which R1 represents a carboxylic acyl radical or an a -alkoxyalkyl radical in which the alky radical of the alkoxy substituent can be bound to the parent chain in the form of a ring, to solvolysis. The 4 - alkyl - 1,2 - diphenyl - 3,5 - dioxopyrazolidine starting materials may be prepared by condensing the appropriate malonic acids with hydrazobenzene derivatives of Formula V <FORM:1045544/C2/2> These compounds in which R1 is alkyl or acyl may also be prepared by condensing a malonic acid dihalide with the appropriate hydrazobenzene, and those in which R1 is alkyl or a -alkoxyalkyl may be prepared by condensing di-alkyl esters or alkyl ester halides of a malonic acid with a hydrazobenzene derivative. The hydrazobenzene compounds may be produced by reducing the corresponding azobenzenes. The starting materials may also be prepared by introducing the 4-alkyl radical into the analogous unsubstituted pyrazoline compounds, e.g. by condensation with a saturated or unsaturated aldehyde and reduction of the 4-alkylidene or 4-alkenylidene compound obtained. Therapeutic compositions useful for the treatment of acute and chronic inflammatory diseases, and possessing antiphlogistic properties, which can be administered orally, rectally or parenterally, contain as active ingredient the compounds of the first formula above or salts thereof. |
| priorityDate | 1963-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.