http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1043156-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1963-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f35886a22c090a960fa3980d9dd2c7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ff29ff9618a9662f812381e734341f7 |
| publicationDate | 1966-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1043156-A |
| titleOfInvention | 10-hydroxy-19-norandrostanes |
| abstract | The invention comprises compounds of formula <FORM:1043156/C2/1> wherein A-B is a <FORM:1043156/C2/2> group and R1 is a hydrogen atom and R2 is a hydroxy group or R1 and R2 together are an oxygen atom, or A-B is a <FORM:1043156/C2/3> group and R1 and R2 are an oxygen atom, and their preparation by (a) oxidizing and alkylating a 3-acyl-10b -hydroxy-19-nor -periplogenin to form a compound of formula <FORM:1043156/C2/4> wherein R3 is a C1- 4 acyl group and R4 is a C1- 4 alkyl group, dehydrating this product to the corresponding D 14(15)-compound, hydrogenating the 14(15) double bond to give the 14,15-saturated compound, reacting this with p-anisyl magnesium bromide to give a compound of formula <FORM:1043156/C2/5> dehydrating this to the corresponding D 17(20)-compoun and subjecting this to ozonization and reduction, followed if desired by oxidation to a 3-keto compound and dehydration to a D 4-compound, or (b) oxidation of 10b -hydroxy-19-nor-testosterone to the corresponding dione. Estrone is prepared by treatment of 10b -hydroxy - 19 - nor - androst - 4 - ene - 3,17 - dione with dry hydrochloric acid in glacial acetic acid. The compounds of the invention have anabolic and diuretic activity and may be used in pharmaceutical compositions in combination with a carrier. |
| priorityDate | 1963-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.