http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1042193-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5528d8d64c9da539b3fa8028a22bede6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1963-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d18d9f6e842cdff3dc982b0ec749c3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e917e3c833d4fb00434d2639dc9a01ca |
| publicationDate | 1966-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1042193-A |
| titleOfInvention | Progesterone derivatives |
| abstract | The invention comprises (a) a process for preparing compounds of formula <FORM:1042193/C2/1> wherein R is a hydrogen atom or a C1- 7 alkyl group, P is a hydrogen atom or one of the possible groups Q, and Q is a C1-7 alkyl or haloalkyl, monocyclic cycloalkyl, cycloalkyl-C1-7 alkyl, monocylic aryl, monocyclic aryl-C1- 7 alkyl, monocyclic heterocyclic or monocyclic heterocyclic-C1-7 alkyl group, or P and Q together with the carbon atom to which they are attached from a monocyclic cycloalkyl or monocyclic heterocyclic group, by 6, 7 dehydrogenation of a corresponding 6-unsubstituted or 6a - or b -alkyl compound with chloranil, followed if desired by hydrolysis to the 16a ,17a -diol and reaction with a carbonyl compound P-CO-Q, and (b) the products specified above wherein R is a hydrogen atom. 16,17-Acetals and ketals of 6-(C1-7 alkyl)-16a , 17a -dihydroxy-progesterones are prepared by treatment of 16a ,17a -dihydroxy-progesterone 3,20-bis-ethylene ketal with perphthalic acid to form the corresponding 5a ,6a -epoxide, reacting this with a C1-- 7 alkyl magnesium bromide to form a 6b -(C1- 7 alkyl)-5a ,16a ,17a -triol -3,20-dione-3,20-bis-ethylene ketal, hydrolysing this to the corresponding 3,20-dione, reacting this with an aldehyde or ketone to form the corresponding 16a ,17a -acetal or ketal, and dehydrating to the corresponding 6b -C1- 7 alkyl-progesterone, followed if desired by epimerization to the corresponding 6a -C1- 7 alkyl-progesterone. The compounds of the invention have progestational activity and may be used in forms suitable for oral administration. |
| priorityDate | 1963-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.