http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1038729-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce010dfc8c8ee1224db9be853afeb081 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 1964-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0a06ae771623bf84d90ab35d9cb0c0e |
| publicationDate | 1966-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1038729-A |
| titleOfInvention | New dihydroquinazolines and their preparation |
| abstract | Novel compounds of the general formula <FORM:1038729/C2/1> and their acid addition salts, in which R is hydrogen, an alkyl or alkoxy radical containing up to 5 carbon atoms, or a halogen atom (especially chlorine), R1 is hydrogen or an alkyl radical containing up to 4 carbon atoms, R2 is an alkyl radical containing up to 4 carbon atoms, a hydroxyalkyl radical containing up to 4 carbon atoms, a cycloalkyl radical (containing 5 or 6 carbon atoms), or an amino radical, or R1 and R2 together with the adjacent nitrogen represent a saturated mononuclear heterocyclic group, especially 1-pyrrolidyl, 1-piperidyl, morpholino, or 4-alkyl- or 4-hydroxyalkyl-1-piperazinyl (the alkyl and hydroxyalkyl groups containing up to 4 carbon atoms) are prepared by condensing an amine of formula HNR1.R2 with a 2-chloro-quinazoline of the formula <FORM:1038729/C2/2> The 2-chloro-quinazolines are prepared by reacting a compound of the general formula <FORM:1038729/C2/3> with sulphur monochloride or sulphuryl chloride. Pharmaceutical compositions, preferably in conventional form for oral or parenteral administration, comprise a compound of the first general formula above, or an acid addition salt thereof, and a pharmaceutical carrier. They have sedative and hypnotic activity. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5756502-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5869665-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6166208-A |
| priorityDate | 1964-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.