| abstract |
The invention comprises: (A) compounds of Formula I <FORM:1036084/C2/1> <FORM:1036084/C2/2> where n2 is 5-7, n3 is 3-5, the sum of n2 + n3 + 2 being 12, and each X is independently = CO or = CHOH; and cyclo-tri and tetra-decane 1,5-, 1,6- and 1,7-diols and 5-, 6- and 7-hydroxy-cyclo-tri and tetra-decanones; (B) the preparation of compounds II where n is 5-9, n1 is 3-5, the sum of n + n1 + 2 being 11-14, and each X1 is independently =CO or =CHOH, by (a) subjecting an appropriate cycloalkanol to the oxygenating activity of a Eumycete micro-organism, (b) oxidizing a diol or keto-alcohol of Formula II to the dione, (c) reducing a dione or keto-alcohol II to the diol, or (d) reducing a dione II to the keto-alcohol; (C) the preparation of esterified compounds by reaction of diols or ketoalcohols with acylating agents corresponding to hydrocarbon carboxylic acids of 1-12C. Product mixtures may be separated, e.g. by chromatography: hydrolysis of esterified compounds giving, e.g. sodium salts is also described. Pharmaceutical compositions comprise the new compounds with carriers (e.g. in oral and parenteral forms), being useful as CNS sedatives and anaesthetics. |