http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1034879-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-65 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-65 |
| filingDate | 1965-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1966-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1034879-A |
| titleOfInvention | Lower alkoxy pyridyl acetones |
| abstract | The invention comprises (3-lower alkoxy-2-pyridyl)-acetones and their preparation by treating 3-lower alkoxy-2-methylpyridine with n-butyl lithium in the presence of an inert solvent such as absolute ether or dry hexane, under an inert atmosphere, adding acetonitrile and acidifying with an aqueous acid solution, treating the aqueous phase of the mixture with an alkali metal hydroxide and methylene chloride, separating the aqueous phase from said mixture and recovering the acetone product from the organic phase. The products of said process may be converted to (3-lower alkoxy-2-piperidyl) acetone by selective reduction of the pyridino ring with hydrogen over rhodium catalyst in acidic solution. The latter compounds are useful for preparing antimalarial quinazolones. The examples describe the preparation of (3-methoxy-2-pyridyl)-acetone, (3-ethoxy - 2 - pyridyl) - acetone, (3 - methoxy - 2-piperidyl) - acetone, (3 - ethoxy - 2 - piperidyl)-acetone. 2 - Lithomethyl - 3 - methoxy pyridine is prepared as in the first stage of the above process in solution, for example, in hexane. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112279805-A |
| priorityDate | 1964-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.