http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1034538-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-82 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-82 |
| filingDate | 1964-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e9bdcafd926002980ee4bf56be25d33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99e2f6282072799f6428b020735dc950 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_100305650d0dbd9ba3bef99b03ea4d65 |
| publicationDate | 1966-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1034538-A |
| titleOfInvention | Novel disubstituted aminoethoxyphenyl amines, ethers and sulfides |
| abstract | Novel compounds of formula <FORM:1034538/C2/1> wherein R1, R2, R3 and R4 are hydrogen, methyl or ethyl, the sum of the carbon atoms of R1 + R2 + R3 + R4 being less than 5, R5 is alkyl, and R6 is alkyl, or R5 and R6 together with the nitrogen atom is pyrrolidino, the alkyl groups having 1-4 carbon atoms, Z is amino, oxygen or sulphur, and R is 4-pyridyl, 3-nitro-2-pyridyl, 5-nitro-2-pyridyl, 5-halo-2-pyrimidyl, 2 - benzothiazolyl, 2 - halo - 4-pyrimidyl, 2,6 - dihalo - 4 - pyrimidyl, or p-nitrophenyl which may be 2-substituted by nitro or amino groups, and the non-toxic acid-addition and quaternary ammonium salts thereof, are prepared by reacting a compound of formula <FORM:1034538/C2/2> wherein A is -OH or <FORM:1034538/C2/3> and B is hydrogen or -2H, with a compound R-Y wherein Y is halogen or -SX, where X is halogen, with the proviso that when Y is -SX, B is hydrogen, and when A is -OH, the compound so formed is reacted with a disubstituted aminoethyl halide to produce the compound of Formula I, and, if desired, converting the compound obtained to a non-toxic acid addition or quaternary ammonium salt. Therapeutic compositions useful as hypocholesteremic agents and which may be administered orally contain as active ingredient compounds of Formula I above. The preparation of the following intermediates is given:-41 - hydroxy - 4 - nitrodiphenyl ether from p-hydroquinone and 4-nitrofluorobenzene; 41-(diethylaminoethoxy)-2-carboxy - 4 - nitro - diphenylamine from p-(2 - diethylaminoethoxy)aniline and potassium 2 - chloro - 5 - nitrobenzoate; and 41 - hydroxy-4 - nitrodiphenyl sulphide from 4 - nitrophenyl-sulphenyl chloride and phenol; p-[2-diethylamino-1-methyl)ethoxy]aniline by condensing 1-diethylamino-2-propanol with 1-fluoro-4-nitrobenzene and reducing the p-[(2-diethylamino-1-methyl)-ethoxy]nitrobenzene formed. |
| priorityDate | 1964-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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