http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1032646-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44bab6d9e8e01bedc43d150958de2ecb |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-46 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 |
filingDate | 1963-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d35ecf812afdeb3e7f8b609a22b1776d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e318218f9002903100c7ec75e4745f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd60d43681db9e1d4e202ba7642969d4 |
publicationDate | 1966-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | GB-1032646-A |
titleOfInvention | Cyclopentyl acetic acid ester derivatives |
abstract | The invention comprises quaternary ammonium salts of the general formula: <FORM:1032646/C2/1> where R represents an alkyl group of 4 to 6 carbon atoms, a cycloalkyl group of 5 to 6 carbon atoms, an aralkyl group where the alkyl parts has 1 to 3 carbon atoms, a phenyl group or a phenyl group substituted by a halogen or alkyl group of 1 to 3 carbon atoms; R1 and R2 are the same or different and represent alkyl groups of 1 to 4 carbon atoms; X is an acid residue preferably a halogen or a p-toluene sulphonate group and Y is a direct link or an alkylene group of 1 to 4 carbon atoms. Quaternary ammonium salts are prepared by quaternizing the corresponding bases with substances such as alkyl halides, dialkyl sulphides and alkyl esters of p-toluene sulphonic acid. The bases are prepared by treating a -R-substituted cyclopentyl acetic acid chlorides, where R is the same as before, which are prepared by treating the free acid with thionyl chloride, with 1-methyl-4-hydroxypiperidine. g - (1 - methyl - 4 - piperidyl)propyl a -cyclopentyl phenyl acetate is prepared by reacting g - (1 - methyl - 4 - piperidyl)propanol with a -cyclopentyl-phenyl acetyl chloride. g - (1 - methyl - 4 - piperidyl)propanol is prepared by hydrogenating g -(4-pyridyl)propanol and treating the resulting g -(4-piperidyl)propanol with methyl iodide. Diethyl cyclopentyl cyclohexenyl malonate is prepared by reacting diethyl cyclopentyl malonate with 1,2-dibromocyclohexane. a -Cyclopentyl cyclohexyl acetic acid is prepared by treating diethyl cyclopentyl cyclohexenyl malonate with alcoholic potassium hydroxide followed by hydrochloric acid, ether extraction and heat treatment to give a -cyclopentyl cyclohexenyl acetic acid which is hydrogenated to give the desired product. a -Cyclopentyl-n-hexyl acetic acid is similarly prepared (omitting the hydrogenation) from diethyl cyclopentyl n-hexyl malonate which is prepared from diethyl cyclopentyl malonate and 1-bromohexane. a -Cyclopentyl-p-methyl phenyl acetonitrile and a -cyclopentyl-p-chlorophenyl acetonitrile are prepared by reacting the corresponding p-substituted phenyl acetonitrile with bromocyclopentane. The corresponding substituted acetic acids are prepared by hydrolysis of the nitriles. 1-ethyl-4-hydroxy piperidine is prepared by reacting 4 - hydroxypiperidine with ethyl bromide. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2467846-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8633225-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4022787-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007141289-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5294719-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7851633-B2 |
priorityDate | 1963-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.