http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1031090-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b6fc801b5bfe5304ffa40d938db6e09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-58 |
| filingDate | 1965-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1966-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1031090-A |
| titleOfInvention | New aryloxyacetic amides, their production and compositions containing same |
| abstract | Novel aryloxyacetic acid amides of formula <FORM:1031090/C2/1> wherein X represents a direct bond, -CH2-, -CH2CH2- or -CH = CH-, R1 is an alkyl group, R2 and R3 are each alkyl groups, and R4 is an alkyl or alkoxy group, the alkyl and alkoxy groups having 1-5 carbon atoms, or R3 and R4 together with the nitrogen represent a saturated heterocyclic radical having 5-7 ring members one of which may be oxygen, are prepared by esterifying the corresponding 2 - alkoxy - 4 - hydroxy - alkyl - phenoxyacetic acid amide compounds or reactive derivatives thereof. Compounds of Formula I wherein X represents -CH2CH2- may be prepared by reducing the propenylene compounds of Formula I in which X represents -CH=CH-. The 2 - alkoxy - 4 - hydroxyalkyl - phenoxyacetic acid diethylamide starting materials (R3 = R4 = Et) may be prepared by reacting a 2 - alkoxy - 4 - hydroxyalkylphenol with chloroacetic acid diethylamide. These may be converted to reactive derivatives, e.g. the 4chloroalkyl derivative, by reaction with thionyl chloride, or the 4-tosyloxyalkyl derivative, by reaction with p-toluenesulphonic acid chloride. 3 - (31 - Ethoxy - 41 - hydroxyphenyl) - propanl-ol may be prepared by esterifying 3-ethoxy4-hydroxycinnamic acid with ethanol, reducing the resulting ethyl 3-ethoxy-4-hydroxycinnamate to ethyl 3-ethoxy-4-hydroxy-hydrocinnamate by catalytic hydrogenation, followed by reduction of the ester group with lithium aluminium hydride.ALSO:Therapeutic compositions useful as short-acting anaesthetics and which may be administered parenterally contain as active ingredient compounds of formula <FORM:1031090/A5-A6/1> wherein X represents a direct bond, -CH2-, -CH2CH2- or -CH=CH-, R1 is an alkyl group, R2 and R3 are each alkyl groups, and R4 is an alkyl or alkoxy group, the alkyl and alkoxy groups having 1-5 carbon atoms, or R3 and R4 together with the nitrogen represent a saturated heterocyclic radical having 5-7 ring members one of which may be oxygen. The compositions may also contain water soluble salts of bile acids such as sodium dehydrocholate, morpholine desoxycholate, or ethanolamine cholate, salts of a -naphthylacetic acid or histamine. |
| priorityDate | 1964-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.