http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1030754-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d629f98a51b15993f56f9e04fdea237f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B62M9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J61-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B62M9-02 |
| filingDate | 1962-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1966-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1030754-A |
| titleOfInvention | Novel d-nor steroids and processes for their manufacture |
| abstract | The invention comprises D-nor-steroids and a process for the production thereof by dissolving a steroid substituted in the D-ring by a keto group and by a diazo group in a position a - to the keto group, in an inert solvent containing a compound which can be added across the double bond of a ketene, photolysing the solution and isolating the D-nor-steroid thus produced. By employing a 16-diazo-17-keto androstane or estrane dissolved in an inert solvent containing water, ammonia, an alcohol or primary or sec. amine, there is produced a D-nor-16b -carboxylic acid, carboxylic amide, carboxylic acid ester or -N-mono- or disubstituted-carboxylic acid amide. Further transformations may be effected, e.g. by converting the D-nor-16b -carboxylic acid to the corresponding acid chloride, followed by reaction with an organo-metallic compound or with diazomethane to form a D-nor-pregnane derivative, degrading the D-nor-pregnane derivative to obtain a D-nor-androstane derivative which on pyrolysis gives a D-nor-estrane derivative. The starting a -diazo-keto steroid may be obtained by reacting the corresponding a -oximino-keto steroid with chloramine. Pharmaceutical compositions containing the above compounds and having estrogenic, androgenic, anti-inflammatory, cortical, cholesterol-lowering, anabolic, progestational and antifertility activity are administered orally or parenterally. |
| priorityDate | 1962-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.