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filingDate 1961-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbbaeb7e253e12df2b6444409c7e2b19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ab8e1e5642ac45a299a48be684967a
publicationDate 1966-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1030301-A
titleOfInvention Improvements in and relating to the manufacture of polypeptides and amino-acids
abstract In a process for the preparation of alanine, ethylidene imine is reacted with carbon monoxide and ammonia under a pressure of 1000 atmospheres and in the presence of sodium metal, the resultant polypeptide being hydrolysed with concentrated hydrochloric acid.ALSO:A process for the manufacture of a polypeptide comprises reacting a Schiff's base with carbon monoxide in the presence of a catalyst and under a pressure of at least 50 atmospheres. A Schiff's base is defined as being a condensation product of an aldehyde or ketone with ammonia or a primary amine but excluding the reaction product of ammonia with formaldehyde. Specified catalysts are sodium, sodamide and the carbonyls of cobalt, tungsten, molybdenum and chromium. In the example ethylidene imine (made from ammonia and acetaldehyde) is reacted with ammonia in the presence of sodium. The product of the example may be hydrolysed to alanine.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008067729-A1
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