http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1028405-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1963-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1966-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1028405-A |
| titleOfInvention | New tetrahydro-pyrido-[4,3-d]-pyrimidines and processes for their preparation |
| abstract | <FORM:1028405/C2/1> The invention comprises 5,6,7,8-tetrahydropyrido-[4,3-d]-pyrimidines of the formula in which R represents a hydrogen atom, or an alkyl group in the 7- or 8-position, R1 represents an aminoalkyl (including a mono- or di-substituted aminoalkyl), alkoxyalkyl, cycloalkyl, aryl or aralkyl group, and R2 represents a hydrogen atom, a hydroxy, alkyl, aryl or aralkyl group, a free or mono- or di-substituted amino group, a nitrogen-containing saturated heterocyclic ring (which may contain a further hetero atom and/or be alkyl- or hydroxyalkyl-substituted) linked to the 2-position of the pyrimidine ring via the nitrogen atom, or an alkylthio or aralkylthio group; non-toxic acid addition salts thereof; and a process for their preparation comprising reacting a piperidone carboxylic acid ester of the formula <FORM:1028405/C2/2> in which Alk is an alkyl group, or an acid addition salt thereof, with a compound of the formula <FORM:1028405/C2/3> or an acid addition salt thereof, and, if desired' converting the compound thus formed to non-toxic acid addition salt of a compound of Formula I. The compounds in which R2 represents a free or mono- or di-substituted amino group, or a saturated heterocyclic ring as defined above, may also be prepared by reacting a compound of Formula I in which R2 represents a mercapto, alkylthio, aralkylthio or halo-aralkylthio group with ammonia or an appropriate primary or secondary amine, and, if desired, the compound of Formula I thus formed may be converted to a non-toxic acid addition salt thereof. Piperidone carboxylic acid esters of Formula II are prepared by the Dieckmann condensation of an ester of the formula <FORM:1028405/C2/4> Pharmaceutical compositions having anti-pyretic, antiphlogistic, diuretic, bacteriostatic, sedative or coronary-dilatory activity for oral, rectal or parenteral administration comprise a compound of the invention together with a pharmaceutical carrier or excipient. The compositions may be formulated as tablets, coated tablets, capsules, suspensions, ampoules or suppositories. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106632318-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8071766-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106632318-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8618290-B2 |
| priorityDate | 1962-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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