http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1021381-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-50 |
| filingDate | 1964-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1966-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1021381-A |
| titleOfInvention | Substituted phenyl aryl ketones and benzodiazepin derivatives prepared from them |
| abstract | The invention comprises o-(2-hydroxyaminoacylamino)-phenyl aryl ketones and their O, N (2)-diacyl derivatives, e.g. of Formula (I) <FORM:1021381/C2/1> wherein ring A may be substituted, R is H, alkyl or aralkyl (up to C9), R1 and R2 are H, alkyl, aryl or aralkyl, R3 and R4 are both H or acyl and Ar is aryl. Such compounds are prepared by reacting hydroxylamine with an o-(2 - substituted - acylamino) - phenyl aryl ketone in which the 2-substituent is subject to nucleophilic displacement by hydroxylamine (e.g. halogen or organic sulphonoxy), and optionally acylating the product under non-cyclizing conditions. The products can be cyclized in acid media to the oxides (II) <FORM:1021381/C2/2> the latter or their salts are also obtained by treating the hydroxyamino compounds with bases. The 3-acyloxybenzodiazepins (III) <FORM:1021381/C2/3> are obtained by acylating (a) oxides (II) (R1 = R2 = H) or (b) the hydroxyamino compounds in acid media. The acyl group in (III) is replaceable by H on hydrolysis. The products of the invention may be converted in situ to (II) and (III), without isolation. |
| priorityDate | 1963-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.