| abstract |
The invention comprises esters of various estrogenic, androgenic and corticoid steroid hormones and N,N-di-(b -haloethyl)-carbamic acids wherein the halogen is chlorine or bromine, and their preparation by (a) reacting either the corresponding steroid alcohol or an N,N-di-(b -haloethyl)-amine with carbonyl chloride or bromide to give the corresponding chloroformyl ester or amide and reacting this intermediate with the other starting material, or (b) esterifying a free hydroxyl group in a product of (a) with a pharmaceutically acceptable organic or inorganic acid. N - Chloroformyl - N,N - di - (b - chloroethyl) - amine is prepared by reaction of N,N-di-(b - chloroethyl)-amine with phosgene. The compounds of the invention have antitumou activity and may be used in combination with a pharmaceutical carrier in forms suitable for oral or parental administration, e.g. as tablets, capsules, solutions or suspensions. |