http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1013574-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0f72c66096c79f62800a395826ee550 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-12 |
| filingDate | 1962-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1013574-A |
| titleOfInvention | A method for preparing new derivatives of 6,11-dihydrodibenz (b,e) thiepin |
| abstract | The invention comprises a method of preparing 6,11-dihydrodibenz (b, e) thiepin derivatives of the general formula <FORM:1013574/C2/1> (wherein R1 and R2 are the same or different and each represent a hydrogen or halogen atom or an alkyl, alkoxy, aryl, aralkyl or alkyl-mercapto group, and either R3, R4 and R5 represent hydrogen atoms, in which case R6 and R7 each represent a C1- 4 alkyl group or jointly represent an alkylene chain, which may be interrupted by an oxygen atom or by a nitrogen atom which may carry a C1- 4 alkyl group, or two of R3, R4 and R5 represent hydrogen atoms and the third is linked to R6 to form an unbranched C2- 4 alkylene chain, in which case R7 represents a C1- 4 alkyl group) and thei acid addition salts, comprising reacting a compound of the general formula <FORM:1013574/C2/2> with a Grignard reagent of the general formula R6R7NCHR5-CHR4-CHR3-MgHal III (wherein Hal represents a halogen atom) and dehydrating the resulting compound of the general formula <FORM:1013574/C2/3> and, if desired, converting the resulting compound I to an acid addition salt; and certain specific compounds obtainable by the foregoing process. The products have antidepressive, ataractic, spasmolytic and antihistaminic properties. Ketones II are prepared by cyclizing suitably substituted S-benzylthiosalicylic acid chlorides or anhydrides in the presence of anhydrous aluminium chloride, or by cyclizing suitably substituted 2-(phenylmercaptomethyl)-benzoic acids by means of polyphosphoric acid. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8058287-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7541365-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8394817-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8653096-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9663537-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7977350-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7732459-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9334283-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7271176-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2125040-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0101234-A1 |
| priorityDate | 1961-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.