http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1012956-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb75b0b19820e3833ebdcb31603b242b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 |
| filingDate | 1963-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1012956-A |
| titleOfInvention | Improvements in or related to n-cyanomorphinan derivatives and their preparation |
| abstract | The invention comprises compounds of the formula <FORM:1012956/C2/1> wherein R represents an alkyl group of not more than 5 carbon atoms, R1 represents a hydrogen atom or an aryloxy group, R11 represents a methylene or carbonyl group and X represents a hydrogen atom or a hydroxyl or acyloxy group, and the preparation thereof by reaction of a compound of the formula <FORM:1012956/C2/2> with a cyanogen halide. The reaction may be carried out at room temperature, but is preferably performed in an inert organic solvent under reflux. (-) - 3 - Methoxy - 6 - oxo - 14 - hydroxy - N - methyl-morphinan (cis) is prepared from the-baine by oxidation to produce the 6-keto derivative, conversion to the oxime, and hydrogenation to give (-)-3-methoxy-4-hydroxy-6-oxo -14-hydroxy-N-methyl-morphinan which is is converted to the 6-phenyloxy-derivative, ketalated, treated with sodium and ammonia to remove the 6-phenyloxy-group and finally deketalated. |
| priorityDate | 1962-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.