http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1012620-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcbc1de8801460caf80ad76627ae20b0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-02 |
| filingDate | 1962-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a398b015f4349cdc2631e1f90bcfe7cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed4b7efd3656d03c6c53d04cea754a8f |
| publicationDate | 1965-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1012620-A |
| titleOfInvention | Isothiazole derivatives |
| abstract | The invention comprises compounds of the formula <FORM:1012620/C2/1> wherein R1 represents a hydrogen or halogen atom or a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group and R3 and R4 are the same or different and each represents a hydrogen atom or a lower alkyl radical, where the term "lower" means that the groups so qualified contain at most 6 carbon atoms, and the preparation thereof by a process wherein an aldehyde or ketone of the formula <FORM:1012620/C2/2> an acetal, diacetate, oxime or semicarbazone thereof is reacted with a thiosemicarbazide of the formula <FORM:1012620/C2/3> or an acid addition salt thereof, and a process for the preparation of compounds of the general formula (I) wherein R7 and R4 represent hydrogen atoms wherein a hydrazone of the formula <FORM:1012620/C2/4> is reacted with an alkali metal thiocyanate in the presence of a mineral acid. Compounds of the general formula (I) when R2 represents a hydrogen atom may be prepared by the reaction of an arylsulphonylcarboxyhydrazide of the formula <FORM:1012620/C2/5> wherein Ar represents an aryl group, with a thiosemicarbazide of the Formula (III) or an acid addition salt thereof. Carbonyl compounds of the Formula (II) may be prepared by reaction of an isothazol-5-yl lithium with an amide of the formula <FORM:1012620/C2/6> wherein R5 and R6 represent lower alkyl groups; by reduction of an isothiazo-5-yl nitrile with lithium trimethoxyaluminium hydride, and by reaction of an isothiazol-5-yl nitrile with a Grignard reagent of the formula R2MgHal where Hal represents a hydrogen atom and R2 represents a lower alkyl group. The arylsulphenylcarboxyhydrazides of the formula (IV) may be prepared by reaction of an isothiazol-5-yl carboxyhydrazide with an arylsulphonylhydrazide. Isothiazol-5-yl lithium derivatives may be prepared by reaction of a 5-unsubstituted isothiazole with an organo-lithium compound, e.g. an alkyl or aryl lithium. Pharmaceutical compositions for oral or parenteral administration, which may take the form of tablets, pills, dispersible powders, granules, emulsions, solutions, suspensions, syrups, elixirs and capsules, having antiviral properties with high activity against the pox group of viruses, comprise compounds of the general formula (I) and a pharmaceutical carrier. For veterinary use, the compounds may be incorporated in animal foodstuffs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5098462-A |
| priorityDate | 1962-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.