http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1011122-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1962-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1011122-A |
| titleOfInvention | 11ª‡-hydroxy-11:19-cyclo-steroids and 19-oxygenated steroids and process for their manufacture |
| abstract | The invention comprises (1) a process for the preparation of 19-oxygenated steroids wherein a 19-unsubstituted 11-oxo-steroid that contains a free oxo group only in position 11 is irradiated with ultra-violet light in a solvent, an 11a -hydroxy-11,19-cyclo-steroid formed is treated in an inert solvent with an oxidizing heavy metal acylate, in any resulting 11-oxo-19-acyloxy-steroid obtained the cyloxy group is hydrolysed and, if desired, an 11-oxo-19-hydroxy-steroid formed is oxidized to an 11,19-dioxo-steroid or an 11-oxo-steroid-19-acid; and (2) as new compounds, the 11a -hydroxy-11,19-cyclo-steroids which are intermediates in this process, and their esters. Suitable acylates for use in the process are lead tetra-acylates, and in most cases the 11-oxo-19-acyloxy-steroids formed undergo hydrolysis even on chromatography on alumina, but they can also be hydrolysed with bases, e.g. with an alcoholic alkali metal hydroxide. Oxidation of the 11-oxo-19-hydroxy steroids with chromium trioxide in basic solution yields 11, 19-dioxo-compounds while in acid solution the 11-oxo-steroid-19-acids are obtained. The steroids used in the present process may be of the androstane, pregnane, cholane, cholestane, spirostane or cardanolide series and may contain as substituents ketalized oxo groups or oxo groups converted into enol derivatives, free, esterified or etherified hydroxyl groups, alkyl, alkenyl or alkynyl groups of halogen atoms in one or several of positions 1, 2, 3, 4, 5, 6, 7, 8, 9, 12, 14, 15, 16, 17, 18, 20, 21, 22 and 23. They may also contain double bonds, for example in positions 5, 6, 13 and 16, or oxido groups. Ketalized oxo groups may subsequently be released. Examples are given. |
| priorityDate | 1961-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.