http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1010031-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1964-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1010031-A |
| titleOfInvention | Improvements in or relating to the preparation of steroids |
| abstract | A steroid 21-dialkali phosphate is obtained by treating a 21-hydroxy steroid with an organic phosphate ester in the presence of a dehydrating agent to obtain the corresponding steroid 21-organophosphate, cleaving the latter in an aqueous base to obtain the corresponding steroid 21-dialkali phosphate in aqueous solution and purifying the latter compound by selective extraction alternately with n-butanol, ether, water containing alternately hydrogen and sodium ions and freeze-drying the aqueous solution containing the 21-dialkali phosphate salt of the steroid. As organic phosphate ester there may be used an ethyl phosphate of the formula <FORM:1010031/C2/1> wherein R is hydrogen or lower alkyl and 2 is a strongly electronegative substituent, e.g. b -cyanoethyl phosphate, and as dehydrating agent a carbodiimide, e.g. dicyclohexyl carbodiimide, may be used. The preferred 21-hydroxy steroid is 6a -methylprednisolone. Pyridinium b -cyanoethyl phosphate is obtained by adding a mixture of pyridine and b -hydroxy-propionitrile to a solution of POCl3 in ether, treating the reaction mixture with barium acetate to obtain barium cyanoethyl phosphate, treating the latter with an acid ion exchange resin to obtain b -cyanoethyl phosphoric acid which with pyridine yields the desired pyridinium b -cyanoethyl phosphate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0106115-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0106115-A3 |
| priorityDate | 1963-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.