http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1003081-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 1961-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e34dfc9b54844c75d95df54022a5cd62 |
| publicationDate | 1965-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1003081-A |
| titleOfInvention | A process for the preparation of 16ª‰-methyl steroids |
| abstract | 17a - Hydroxy - 20 - keto - 16b - methyl steroids are prepared by hydrogenating 17a -hydroxy - 20 - keto - 16 - methylene steroids in the presence of an iridium catalyst. The iridium may be unsupported or supported on, for example, barium sulphate, kieselguhr or calcium carbonate, and it may be formed in situ by reduction of iridium dioxide. The 16b -methyl steroid may be separated from concomitantly formed 16a -methyl steroid by, for example, repeated crystallization. The steroids may contain, for example, 3-acyloxy, -hydroxy or -keto groups; 11-acyloxy, -hydroxy or -keto groups; 9,11-dichloro substituents; D 9(11)-double bonds; and 5a - or 5b -hydrogen atoms, in addition to the normal 17-substituents of pregnane compounds. Reduction of some of these groups, e.g. 3-keto, may occur during the process, but D 9(11)-double bonds are, in general, not effected. Examples are provided. 11b ,21 - Diacetoxy - 3b ,17a - dihydroxy - 16 - methylene - 5a - pregnan - 20 - one is prepared from 3b ,11b -diacetoxy-5a -pregn-16-en-20-one by the steps of reaction with diazomethane, pyrolysis to form the 16-methyl-16(17)-ene compound, epoxidation, rearrangement with acid to a 17a -hydroxy-16-methylen compound, bromination to a 21-bromide and reaction with potassium acetate. Specifications 956,271, 956,272, and 1,003,082 are referred to. |
| priorityDate | 1961-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.