| abstract |
The invention comprises compounds of formula <FORM:1001093/C2/1> wherein R is a hydrogen atom or an acyl radical and R1 is a phenyl radical optionally substituted by one or more halogen atoms and/ or alkyl, hydroxy, alkoxy, nitro, amino and/or acylamino radicals, physiologically acceptable acid addition salts thereof, and their preparation by (a) reacting phenylated g -thiocyanopropylamines with a weak alkali, (b) reacting a phenylated N-t-butyl-N1-g -hydroxypropylthiourea, or a phenylated N-g -hydroxypropylthiourea, with an acid, (c) reacting a phenylated g - halopropylisothiocyanate or a phenylated 2 - mercapto- or 2 - alkylmercapto - 4H - 5,6-dihydro - 1,3 - thiazine with ammonia or an ammonia-yielding agent, (d) heating a phenylated g - aminopropylisothiourea ether hydrohalide, or (e) reacting a phenylated 1,3-dihalopropane with thiourea, and, if desired, acylating the product obtained. The compounds of the invention have circulation-stimulating activity. 3 - Chloro - 1 - phenyl - propyl - 1 - isothiocyanate is prepared by reaction of 3-chloro-1-phenyl -propyl-1-amine and thiophosgene. 1 - Phenyl - 1 - amino - propyl - 3 - isothiourea hydrobromide is prepared by reaction of 3-amino-3-phenyl-propyl-1-bromide and thiourea. |