http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1000505-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e847ba056c00fe5c2619d20924ffa76b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 1961-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1000505-A |
| titleOfInvention | 2-(ª‡-oxo-aralkyl)benzimidazole compounds, and process of making same |
| abstract | The invention comprises compounds of the formula <FORM:1000505/C2/1> and their pharmaceutically acceptable acid addition salts, wherein R is a dialkylamino alkyl, monoalkylamino alkyl, hydroxy alkyl, piperidino alkyl, or morpholino alkyl group. R1 is an aralkyl group of the formula <FORM:1000505/C2/2> <FORM:1000505/C2/3> wherein n is 0 or an integer from 1 to 4, m is an integer from 1 to 4 and R2 to R6 are hydrogen or halogen atoms or alkoxy, nitro, amino, monoalkylamino, dialkylamino, monoacylamino or C1- 5-alkyl groups, and the preparation thereof either by reacting a compound of the formula <FORM:1000505/C2/4> with an alkyl halide R-Hal in the presence of agents capable of splitting off and binding hydrogen halide; or by reacting a compound of the general formula <FORM:1000505/C2/5> with agents capable of oxidizing a secondary alcohol group to a keto group; or by reacting a compound of the general formula <FORM:1000505/C2/6> wherein R8 is halogeno alkyl, with a mono- or dialkyl-amine, piperidine or morpholine. 2 - a - Hydroxybenzimidazoles are prepared from an N-substituted or -unsubstituted o-phenylene diamine and an appropriate mandelic acid or its imino ether. 2 - a - Ketobenzimidazoles of Formula V are prepared by oxidation of the corresponding 2-a -hydroxybenzimidazole with selenium dioxide. Benzimidazoles of Formula VI are prepared from the corresponding 1-hydroxy alkyl derivatives by halogenation. 4-Methoxy phenyl lactic acid nitrile is prepared from anisaldehyde and monochloroacetic acid to form the 4-methoxyphenylacetaldehyde and reacting the bisulphite with a cyanide. The nitrile is converted into the imino ether. Pharmaceutical compositions, having analgesic and spasmolytic activity, contain the compounds of the invention and may be formulated as tablets, pills, dragees, capsules, suppositories and solutions for parenteral administration. |
| priorityDate | 1960-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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