http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-8304-M
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D11-0492 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-23 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 |
| filingDate | 1968-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1970-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-8304-M |
| abstract | 1,219,316. Thyrocalcitonin extraction. MERCK & CO Inc. 8 July, 1968 [14 July, 1967], No. 32477/68. Heading A5B. The hypocalcemic peptide thyrocalcitonin is obtained in a pure state from a thyroid gland extract by the process comprising countercurrent extraction with a two phase, five component solvent system consisting essentially of pyridine, n-butanol, acetic acid, ammonium acetate and water in the proportions of 60-100 ml. of pyridine, 100 ml. of n-butanol, 1.2 to 5 ml. of acetic acid, 100 to 300 ml. of water, and 1 to 5 grams of ammonium acetate. The product of the extraction process may be further purified by countercurrent extraction with a two phase, three component n-butanolwater-acetic acid system, alternatively, the procedure may be reversed. The 3-component system may also be used before and after treatment with the 5-component system. The product may be further purified by conventional chromatographic or gel filtration methods. The preferred starting material is porcine thyroid glands and in particular a crude extract of the defatted gland obtained by extraction with a solvent system similar or the same as that used for the countercurrent extraction process. Reference is also made to pharmaceutical compositions containing as the active ingredient the product of the process of the invention. |
| priorityDate | 1967-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.