| abstract |
The present invention relates to metformin, its salts, or its complexes, for its topical use to reduce inflammation of the skin, in particular to reduce protein glycation of the skin, more particularly of the dermis. The present invention relates to the topical use of metformin, its salts, or its complexes to reduce the load of AGEs, to inhibit the expression of the gene coding for the RAGE receptor and the protein abundance of RAGE and thus to reduce the secretion of IL-8.n Finally, the present invention also relates to the topical use of metformin, its salts, or its complexes to activate and improve the reconstruction of the skin, in particular of the dermis, thus accelerating the healing of wounds. |