http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-3075200-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f6be7b5f316f050e9151b3afd8936f7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-283 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 |
| filingDate | 2017-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eabc710e8ad53f44bf310cb24eee059a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1846b6eef0b43f348cbdde28d51fadb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7aa5fdd03c97ad7893d6da17f00d9f69 |
| publicationDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-3075200-A1 |
| titleOfInvention | VARIANTS WITH FC FRAGMENT HAVING INCREASED AFFINITY FOR FCRN AND INCREASED AFFINITY FOR AT LEAST ONE FRAGMENT FC RECEPTOR |
| abstract | The subject of the present invention is a variant of a parent polypeptide comprising an Fc fragment, said variant having an increased affinity for the FcRn receptor, and an increased affinity for at least one receptor for the Fc fragment (FcR) chosen from FcγRI receptors ( CD64), FcγRIIIa (CD16a) and FcγRIIa (CD32a), compared to that of the parent polypeptide, characterized in that it comprises:n (i) a mutation chosen from 434Y, 378V, 378T, 434S, 226G, P228L, P228R, 230S, 230T, 230L, 241 L, 264E, 307P, 31 5D, 330V, 362R, 389T and 389K; andn (ii) at least one mutation chosen from 334N, 326E, 326T, 352L, 378V, 378T, 396L, 397M, 421 T, 334R, 307N and 394P;n (iii) at least one mutation chosen from 352S, 226Y, 227S, 231V, 234P, 243I, 246R, 246E, 247T, 248E, 253F, 254F, 255W, 259A, 261 R, 262A, 263A, 266M, 267N, 267G, 274E, 274R, 276S, 278H, 282A, 283G, 284L, 286I, 286Y, 287T, 288E, 288R, 298N, 302A, 308A, 308G, 309P, 31 2G, 31 6D, 319H, 320T, 320R, 320M, 322E, 323I, 333G, 334N, 334R, 336T, 339T, 340E, 343S, 345G, 349S, 349H, 350A, 359A, 361 H, 363I, 366A, 373D, 375R, 377T, 378V, 378T, 379A, 380G, 383R, 385R , 389S, 393A, 393I, 394P, 397I, 397M, 398P, 405V, 405L, 41 0R, 41 2M, 41 4R, 421 S, 423L, 423Y, 423S, 423P, 428T, 431V, 431 T, 434K, 434S, 435R, 436H, 440G, 440N, 442F, 442P and 447N, the numbering being that of the EU index or equivalent in Kabat and with the condition that mutations (i), (ii) and (iii) do not take place on the same amino acids.n It also relates to a process for producing such a variant, in particular by transgenic route. |
| priorityDate | 2017-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.