http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-3033334-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_86ee12d0571e904c7f32fa9ffecd0808 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66 |
| filingDate | 2015-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d063e06633da9fe06410a831e7df8805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b33021f30c116467b79640e2d49be10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b2e784219fb83b1f9828f1cad79f887 |
| publicationDate | 2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-3033334-A1 |
| titleOfInvention | NON-RADIOACTIVE METHOD FOR DETERMINING THE CYTOLYTIC ACTION OF AN AGENT FOR TARGET CELLS, USE THEREOF AND KIT THEREOF |
| abstract | Non-radioactive method for direct in vitro determination (control and quantification) of the cytolytic action of an agent active against target cells and / or a target cell environment, comprising the steps of genetic transformation of target cells for expressing an enzyme exogenous to said target cells, exposing said target cells genetically transformed to the active agent and / or said environment to be tested, which can lead to the lysis of at least a portion of the target cells by releasing said exogenous enzyme in the extracellular medium, and measuring the activity of the exogenous enzyme released during the lysis of said target cells, characterized in that said exogenous enzyme is an enzyme of molar mass less than or equal to 45 kDa , and whose activity is detectable by luminescence or fluorescence. Application to measurement of antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and / or measurement of apoptosis. |
| priorityDate | 2015-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 281.