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filingDate 2012-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eaddebac858cb8293996c1ba2f2cc76
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publicationDate 2013-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber FR-2990697-A1
titleOfInvention METHOD OF ATTENUATING A BACTERIUM OF THE MYCOBACTERIUM TUBERCULOSIS COMPLEX FOR THE MANUFACTURE OF A VACCINE AGAINST TUBERCULOSIS
abstract The present invention relates to a method for decreasing the growth of a Mycobacterium tuberculosis mycobacterium strain in eukaryotic cells by adding and expressing in said mycobacterium an mspA gene encoding a porin A of Mycobacterium smegmatis, as well as a strain thus transformed useful for the manufacture of a vaccine for the prevention of infection by a bacterium of the Mycobacterium tuberculosis complex in a host comprising said eukaryotic cells, preferably macrophages.
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