| abstract |
The invention relates to a ligand of a luteinizing hormone (LH), characterized in that it comprises the paratope of an anti-ovine LH antibody whose variable domain of the heavy chain contains the following CDRs: - VH-CDR1, defined by the sequence GYTFTNYW (SEQ ID NO: 13); - VH-CDR2, defined by the sequence IYPGGGYT (SEQ ID NO: 14); VH-CDR3, defined by the sequence ARTPLYGSSYGGFAY (SEQ ID NO: 15); and the variable domain of the light chain contains the following CDRs: VL-CDR1, defined by the sequence QGISNY (SEQ ID NO: 16); - VL-CDR2, defined by the sequence YTS; VL-CDR3, defined by the sequence QQYSKLPWT (SEQ ID NO: 17). The invention also relates to a ligand-gonadotropin complex (LH, hCG, FSH). The ligand or complex according to the invention can be used to induce ovulation in a female mammal |